Manipulation of synthetic molecular motors
Molecular shuttles are perhaps one of the simplest examples of molecular devices and have long been considered candidates for the construction of molecular motors. Structurally, molecular shuttles are rotaxanes in which the macrocycle can move between two (or more) regions of the thread, called stations, in response to an external stimulus. The shuttling motion of an ensemble of these molecules has been shown to perform mechanical work collectively during a single switching step, but whether they perform as molecular motors remains an unanswered question. In collaboration with the lab of Emilio M. Pérez we brought together biochemistry, chemical synthesis and single-molecule manipulation for designing a set of experiments to directly test the mechanics and dynamics behind the operation of these synthetic devices.
To accomplish our objective we first learned how to couple synthetic organic molecules with DNA, for their manipulation with the optical tweezers. Check our recent work on this topic Naranjo T. et al Chemical Science 2017, which has been highlighted by the Royal Society of Chemistry in Chemistry World.