MOLECULAR MOTORS
MANIPULATION LAB
The use of nanomotors to power molecular machines is one of the most exciting challenges facing nanotechnology. Our laboratory uses nanoscale principles and techniques to understand at the molecular level the physical-chemical and mechanistic principles of operation of biological and synthetic molecular motors. Using nature as a guide will facilitate the design of highly efficient ‘man-made’ molecular machines for complex operations at the nanoscale.
Research
News
Do you wanna know how our mitochondrial DNApol deals with SSBs?
Check out our recent work at NAR!!
Our lab funded by the Spanish Ministry of Science for 3 more years , 2019-2021!!
Our work on molecular shuttles selected as Nature Communication editor’s highligth!
Check our contribution to the blog of Nature Research Chemistry Community
Five minutes in the life of a molecular shuttle
Our work describing the dynamics of artificial molecular shuttles is already out in Nature Communications
Dynamics of individual molecular shuttle under mechanical force
New issue of Biofisica Magazine! check it out is pretty cool
The new issue of the Spanish Biophysical Society just released! check it out!!
Recent Publications
Understanding the paradoxical mechanical response of in-phase A-tracts at different force regimes
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Dynamic constriction and fission of ER membranes by reticulon
Javier Espadas, Diana Pendin, Rebeca Bocanegra, et al
Nature Communications, Volume 10, Article number: 5327 (2019)
Replicative DNA polymerases promote active displacement of SSB proteins during lagging strand synthesis
Cerron, Fernando; de Lorenzo, Sara; Lemishko, Kateryna; Ciesielski, Grzegorz ; Kaguni, Laurie; Cao, Francisco; Ibarra, Borja.
Nucleic Acids Research, 47(11), 5723–5734 (2019)
Dynamics of individual molecular shuttles under mechanical force.
Teresa Naranjo, Kateryna M. Lemishko, Sara de Lorenzo, Álvaro Somoza, Felix Ritort, Emilio M. Pérez & Borja Ibarra
Nature Communications, Volume 9, Article number: 4512 (2018)
DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein.
JA Morin, F Cerrón, J Jarillo, E Beltrán-Heredia, GL Ciesielski, JR Arias-Gonzalez, LS Kaguni, FJ Cao, B Ibarra.
Mechanical measurement of hydrogen-bonded host-guest systems under non-equilibrium, near-physiological conditions.
T. Naranjo, F. Cerrón, B. Nieto-Ortega, A Latorre, A Somoza, B. Ibarra*, M. Pérez*
*corresponding authors
Chemical Science, 8, 6037-6041, (2017).
Highlighted by the Royal Society of Chemistry in Chemistry World
Mechanics, Thermodynamics, and kinetics of ligand binding to biopolymers.
J. Jarillo, E. Beltrán, J Morín, J.P. García-Villaluenga, B. Ibarra, F. Cao
Kinetic modeling of molecular motors: pause model and parameter determination from single molecule experiments.
Morin J.A. ,Ibarra B. ,Cao F.J.
Journal of Statistical Mechanics: Theory and Experiments 2016(5) 054031
Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase.
J.A. Morín, F.J. Cao, J.M. Lázaro, J.R. Arias-Gonzalez, J.M. Valpuesta, J.L. Carrascosa, M. Salas and B. Ibarra.
Manipulation of single polymerase-DNA complexes: a mechanical view of DNA unwinding during replication.
J.A. Morin, F.J. Cao, J.M. Valpuesta, J.L. Carrascosa, M. Salas, B. Ibarra.
Active DNA unwinding dynamics during processive DNA replication.
J.A. Morín, F.J. Cao, J.M. Lázaro, J.R. Arias-Gonzalez, J.M. Valpuesta, J.L. Carrascosa, M. Salas, B. Ibarra.
Proceedings of the National Academic of Sciences USA, 109(21), 8115-8120, (2012)
Mechanical properties of high-G.C content DNA with a-type base-stacking.
Hormeño S. ,Ibarra B. ,Carrascosa J.L. ,Valpuesta J.M. ,Moreno-Herrero F. ,Arias-Gonzalez J.R.
Proofreading Dynamics of a Processive DNA Polymerase.
Ibarra B. ,Chemla Y. ,Plyasunov S. ,Smith S.B. ,Salas M. ,Bustamante, C.
