MOLECULAR MOTORS
MANIPULATION LAB
The use of nanomotors to power molecular machines is one of the most exciting challenges facing nanotechnology. Our laboratory uses nanoscale principles and techniques to understand at the molecular level the physical-chemical and mechanistic principles of operation of biological and synthetic molecular motors. Using nature as a guide will facilitate the design of highly efficient ‘man-made’ molecular machines for complex operations at the nanoscale.
Research
News
Optical tweezers trap the Nobel Prize in Physics 2018!! Congrats A. Ashking, you’re the man!!
Our work about the dynamics of a synthetic molecular switch accepted for publication in Nat Comm !!!
Our work in collaboration with the lab Emilio M Pérez lab (IMDEA Nanociencia) has been recently accepted for publication. Take a quick look to the pre-print posted in Chemrxiv CONGRATS EVERYBODY FOR THE GREAT WORK!!! And more is to...
IMDEA International Workshop on Nanoscale Imaging and Manipulation in Life and Materials Sciences
We are organizing the next IMDEA International Workshop on Nanoscale Imaging and Manipulation in Life and Materials Sciences. Great invited speakers in a great research environment! Join us the next 8th and 9th of October 2018 on IMDEA...
Testing the mechancial strength of H-bonds
Check out our new method to measure at the single molecule level the strength of H-bonds. It was published on Chemical Science and highligthed by the Royal Society of Chemistry magazine Chemistry World. This is our first work in collaboration with the lab of Emilio M....
DNA replication influences the binding mode of the mitochondrial SSB to ssDNA
We have shown that the gradual replication of DNA selects the binding mode of the mitochondrial SSB protein. Check out our work in Morin, Cerron, et al NAR 2017. Congrats everybody!!! and thank you very much to the labs of our collaborators, F.J. Cao (U. Complutense)...
Our work about the binding mode of the mitochondrial SSB proteins has been published in NAR
May 2017. Our work to determine the binding mode of the mitochondrial SSB proteins has been accepted for publication and is already on line!!
Recent Publications
DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein.
JA Morin, F Cerrón, J Jarillo, E Beltrán-Heredia, GL Ciesielski, JR Arias-Gonzalez, LS Kaguni, FJ Cao, B Ibarra.
Mechanical measurement of hydrogen-bonded host-guest systems under non-equilibrium, near-physiological conditions.
T. Naranjo, F. Cerrón, B. Nieto-Ortega, A Latorre, A Somoza, B. Ibarra*, M. Pérez*
*corresponding authors
Chemical Science, 8, 6037-6041, (2017).
Highlighted by the Royal Society of Chemistry in Chemistry World
Mechanics, Thermodynamics, and kinetics of ligand binding to biopolymers.
J. Jarillo, E. Beltrán, J Morín, J.P. García-Villaluenga, B. Ibarra, F. Cao
Kinetic modeling of molecular motors: pause model and parameter determination from single molecule experiments.
Morin J.A. ,Ibarra B. ,Cao F.J.
Journal of Statistical Mechanics: Theory and Experiments 2016(5) 054031
Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase.
J.A. Morín, F.J. Cao, J.M. Lázaro, J.R. Arias-Gonzalez, J.M. Valpuesta, J.L. Carrascosa, M. Salas and B. Ibarra.
Manipulation of single polymerase-DNA complexes: a mechanical view of DNA unwinding during replication.
J.A. Morin, F.J. Cao, J.M. Valpuesta, J.L. Carrascosa, M. Salas, B. Ibarra.
Active DNA unwinding dynamics during processive DNA replication.
J.A. Morín, F.J. Cao, J.M. Lázaro, J.R. Arias-Gonzalez, J.M. Valpuesta, J.L. Carrascosa, M. Salas, B. Ibarra.
Proceedings of the National Academic of Sciences USA, 109(21), 8115-8120, (2012)
Mechanical properties of high-G.C content DNA with a-type base-stacking.
Hormeño S. ,Ibarra B. ,Carrascosa J.L. ,Valpuesta J.M. ,Moreno-Herrero F. ,Arias-Gonzalez J.R.
Proofreading Dynamics of a Processive DNA Polymerase.
Ibarra B. ,Chemla Y. ,Plyasunov S. ,Smith S.B. ,Salas M. ,Bustamante, C.
