+34 912998863 borja.ibarra@gmail.com



The use of nanomotors to power molecular machines is one of the most exciting challenges facing nanotechnology. Our laboratory uses nanoscale principles and techniques to understand at the molecular level the physical-chemical and mechanistic principles of operation of biological and synthetic molecular motors. Using nature as a guide will facilitate the design of highly efficient ‘man-made’ molecular machines for complex operations at the nanoscale.

Recent Publications

Understanding the paradoxical mechanical response of in-phase A-tracts at different force regimes

Alberto Marin-GonzalezCesar L. PastranaRebeca BocanegraAlejandro Martín, GonzálezJ.G. VilhenaRubén PérezBorja IbarraClara Aicart-RamosFernando Moreno-Herrero

Nucleic Acids Research, April 13, 2020

Dynamic constriction and fission of ER membranes by reticulon

Javier Espadas, Diana Pendin, Rebeca Bocanegra, et al

Nature Communications, Volume 10, Article number: 5327 (2019)

Replicative DNA polymerases promote active displacement of SSB proteins during lagging strand synthesis

Cerron, Fernando; de Lorenzo, Sara; Lemishko, Kateryna; Ciesielski, Grzegorz ; Kaguni, Laurie; Cao, Francisco; Ibarra, Borja.

Nucleic Acids Research,  47(11), 5723–5734 (2019)

Dynamics of individual molecular shuttles under mechanical force.

Teresa Naranjo, Kateryna M. Lemishko, Sara de Lorenzo, Álvaro Somoza, Felix Ritort, Emilio M. Pérez & Borja Ibarra

Nature Communications, Volume 9, Article number: 4512 (2018)

DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein.

JA Morin, F Cerrón, J Jarillo, E Beltrán-Heredia, GL Ciesielski, JR Arias-Gonzalez, LS Kaguni, FJ Cao, B Ibarra.

Nucleic Acids Research, 45(12), 7237-7248, (2017)

Mechanical measurement of hydrogen-bonded host-guest systems under non-equilibrium, near-physiological conditions.

T. Naranjo, F. Cerrón, B. Nieto-Ortega, A Latorre, A Somoza, B. Ibarra*, M. Pérez*
*corresponding authors

Chemical Science, 8, 6037-6041, (2017).
Highlighted by the Royal Society of Chemistry in Chemistry World

Mechanics, Thermodynamics, and kinetics of ligand binding to biopolymers.

J. Jarillo, E. Beltrán, J Morín, J.P. García-Villaluenga, B. Ibarra, F. Cao

PLoS ONE 12(4): e0174830 (2017)

Kinetic modeling of molecular motors: pause model and parameter determination from single molecule experiments.

Morin J.A. ,Ibarra B. ,Cao F.J.

Journal of Statistical Mechanics: Theory and Experiments 2016(5) 054031

Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase.

J.A. Morín, F.J. Cao, J.M. Lázaro, J.R. Arias-Gonzalez, J.M. Valpuesta, J.L. Carrascosa, M. Salas and B. Ibarra.

Nucleic Acids Research 43(7), 3643-3652 (2015)

Manipulation of single polymerase-DNA complexes: a mechanical view of DNA unwinding during replication.

J.A. Morin, F.J. Cao, J.M. Valpuesta, J.L. Carrascosa, M. Salas, B. Ibarra.

Cell Cycle 11(16), 2967-2968 (2012)

Active DNA unwinding dynamics during processive DNA replication.

J.A. Morín, F.J. Cao, J.M. Lázaro, J.R. Arias-Gonzalez, J.M. Valpuesta, J.L. Carrascosa, M. Salas, B. Ibarra.

Proceedings of the National Academic of Sciences USA, 109(21), 8115-8120, (2012)

Mechanical properties of high-G.C content DNA with a-type base-stacking.

Hormeño S. ,Ibarra B. ,Carrascosa J.L. ,Valpuesta J.M. ,Moreno-Herrero F. ,Arias-Gonzalez J.R.

Biophysical Journal 100(8), 1996-2005, (2011)

Proofreading Dynamics of a Processive DNA Polymerase.

Ibarra B. ,Chemla Y. ,Plyasunov S. ,Smith S.B. ,Salas M. ,Bustamante, C.

EMBO Journal 28, 2794 -2802, (2009)