Check our new work about how the mitochondrial polymerase and SSB coordinate their activities
https://doi.org/10.1093/nar/gkad037 Many replicative DNA polymerases couple DNA replication and unwinding activities to perform strand displacement DNA synthesis, a critical ability for DNA metabolism. Strand displacement is tightly regulated by partner proteins, such...
It’s not OK for us to say it, but we’ve written a great review about in singulo studies on DNA replication. Check it out!
Click here to enjoy!!
Have a look to our first ever single-molecule fluorescence results with Lumicks C-trap
We are using the new and fancy Lumicks Ctrap at Fernando Moreno' lab (CNB) to track the real-time kinetics of Pfh1 helicase moving along single stranded DNA. The image above shows the trajectory of a single helicase (blue) tagged with a quantum dot along...
Interested in ubiquitous SSB?? Check this out!
New volume of Methods and Molecular Biology on Single Stranded DNA Binding Proteins edited by Marcos Oliveira. This volume provides a comprehensive set of protocols that can be used by any research lab to investigate diverse functional and structural properties of...
Do you wanna know how our mitochondrial DNApol deals with SSBs?
Check out our recent work at NAR!!
Our lab funded by the Spanish Ministry of Science for 3 more years , 2019-2021!!
Our work on molecular shuttles selected as Nature Communication editor’s highligth!
Check our contribution to the blog of Nature Research Chemistry Community
Five minutes in the life of a molecular shuttle
Our work describing the dynamics of artificial molecular shuttles is already out in Nature Communications
Dynamics of individual molecular shuttle under mechanical force
New issue of Biofisica Magazine! check it out is pretty cool
The new issue of the Spanish Biophysical Society just released! check it out!!
Optical tweezers trap the Nobel Prize in Physics 2018!! Congrats A. Ashking, you’re the man!!
Our work about the dynamics of a synthetic molecular switch accepted for publication in Nat Comm !!!
Our work in collaboration with the lab Emilio M Pérez lab (IMDEA Nanociencia) has been recently accepted for publication. Take a quick look to the pre-print posted in Chemrxiv CONGRATS EVERYBODY FOR THE GREAT WORK!!! And more is to come....
IMDEA International Workshop on Nanoscale Imaging and Manipulation in Life and Materials Sciences
We are organizing the next IMDEA International Workshop on Nanoscale Imaging and Manipulation in Life and Materials Sciences. Great invited speakers in a great research environment! Join us the next 8th and 9th of October 2018 on IMDEA Nanociencia
Testing the mechancial strength of H-bonds
Check out our new method to measure at the single molecule level the strength of H-bonds. It was published on Chemical Science and highligthed by the Royal Society of Chemistry magazine Chemistry World. This is our first work in collaboration with the lab of Emilio M....
DNA replication influences the binding mode of the mitochondrial SSB to ssDNA
We have shown that the gradual replication of DNA selects the binding mode of the mitochondrial SSB protein. Check out our work in Morin, Cerron, et al NAR 2017. Congrats everybody!!! and thank you very much to the labs of our collaborators, F.J. Cao (U. Complutense)...
Our work about the binding mode of the mitochondrial SSB proteins has been published in NAR
May 2017. Our work to determine the binding mode of the mitochondrial SSB proteins has been accepted for publication and is already on line!!
Carlos Rodriguez Pulido joined our lab
March 2017. Carlos Rodriguez Pulido joined our lab as a PhD Student to study viral replication dynamics. Welcome Carlos!
The Madrid Government granted our lab
December 2016. The Madrid Government granted our lab with a PhD fellowship (PEJD-2016/IND-2451)
Fernando Cerrón got a PhD fellowship from Universidad Complutense
November 2016. Fernando Cerrón got a PhD fellowship from Universidad Complutense. Congrats Fernando!
The Spanish Ministry of Economy and Competitiveness just granted our proposal
The Spanish Ministry of Economy and Competitiveness just granted our proposal to study the operation of the human mitochondrial replisome at single molecule level!!